Improving VO2 max for healthy and long life

VO2 max image

Introduction

During the lockdown in 2020, I gained around 10 kg (22 pounds). The main cause was eating like a pig and not being active as I previously was. The only reason I left the house was to get more food. After a year, I started going to work and thought just being active again would be enough to shed the extra weight. Soon I realized it was not going to be as easy as it was at 22. At 28, it took me a year of working out fairly regularly to lose weight. If I put myself in the same situation again when I am 38, it will be 4 times as hard to lose even a few pounds. 


As a person not at any health risk (like morbid obesity, smoking, or excessive drinking), you might start noticing age-related health changes like:

  • Changes in your metabolism in your 30s.
  • Muscle mass and strength start to decline in the 40s.
  • For women in their 50s (post-menopause), estrogen depression makes women more vulnerable to health problems like cardiovascular diseases, osteoporosis, cognitive impairment, and different types of cancer (NAMS, 2014).

If you are in your twenties, you might have already started observing physical and cognitive changes in your parents or grandparents.

“Now, here, you see, it takes all the running you can do, to keep in the same place. If you want to get somewhere else, you must run at least twice as fast as that.” – Phil Knight, Shoe Dog: A Memoir by the Creator of NIKE

In the book, it is in the context of business but I think it applies to health as well. The rate of decline in overall health with age is not the same for everyone. People who are 60 but don’t look 60, have put in extra time and effort to maintain their health over the years.


The importance of strength training and its effect on comorbidities when you get older cannot be talked about enough. The focus of this post is to look at some of the ways to prolong a healthy state of body and mind (health span).

  • The first step is to figure out if there is a measurable variable that’s associated with the risk of age-related comorbidities and mortality rate.
  • The second step is to determine what’s my current fitness status based on that measure and how much I need to improve.

VO2 max as a measure of Cardiorespiratory Fitness

Cardiorespiratory fitness (CRF) can be directly measured as maximal oxygen consumption (VO2 max) from a cardiopulmonary exercise testing or is often estimated as the exercise capacity from an exercise test (reference standards for CRF).


Last Monday, I was listening to the Huberman Lab podcast, and the guest on the episode Dr. Peter Attia briefly talked about a recent study that looked at the association between cardiorespiratory fitness and long-term mortality. The average age of the study participants was 53.4 [s.d., 12.6] years. Patients were categorized into 5 groups based on their cardiovascular performance: 

  1. Elite (≥97.7th percentile), 
  2. High (75th-97.6th percentile), 
  3. Above average (50th-74th percentile), 
  4. Below average (25th-49th percentile), and 
  5. Low (<25th percentile). 

Based on the classification of CRF by age and sex in the study (Table 2), and my VO2 max estimate from previous workouts and an online calculator, I’ll fall in the ‘Above average’ cardiovascular performance category.


Assuming that at age 50 I will still be in the above-average category, let’s look at the results of the study.

  • Difference in the prevalence of comorbidities in the 5 performance groups

As shown in Table 1 below, the prevalence of associated comorbidities decreased significantly with increasing performance with the exception of hyperlipidemia. Eg. the prevalence of diabetes is 8.1% in the above-average group vs 2.4% in the elite CRF performance group.

Patient demographics table

  • Difference in long-term mortality in the 5 performance groups.

Over the long term (median follow-up of 8.4 years; range, 4.3-13.4 years), patients in the above-average performance group showed a 42% increase in the risk of all-cause mortality compared to the High-performance group. Which is comparable to the risk of mortality among smokers (41%) and having diabetes (40%).

Adjusted HR by comorbidities and CRF performance group
Adjusted hazard ratios (HRs) for clinical comorbidities and among performance groups.

So, the study shows high CRF is significantly associated with decreased risk of long-term mortality. It also shows high CRF participants have a lower prevalence of related comorbidities compared to lower CRF groups. 

What can we do now to be in the higher CRF performance group?

Take a guess. Yes, EXERCISE. Why doesn’t the answer change? Why is there no alternative solution yet? Why do I have to sweat to have a long healthy life? All those resources to find an alternate planet to live on should be re-routed on this issue. What do you prefer Mars landing or no leg day ever again?


Strength training in particular has a positive effect on cardiovascular fitness, muscle strength, and bone strength. It is a form of exercise in which you provide more than usual resistance to your muscles in order to build strength and increase endurance (Introduction to strength training). The resistance could be your body weight, dumbbells, resistance bands, or kettlebells. Obviously, the training plan will be different for different age groups, sex, and other factors. Everyone should do plenty of research before lifting even 500 grams of weight (Tips for safe strength training).

Multi-system anti-aging effects regular exercise

Disclaimer: This blog is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this blog or materials linked to this blog is at the user’s own risk. The content of this blog is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard, or delay in obtaining, medical advice for any medical condition they may have, and should seek the assistance of their health care professionals for any such conditions.

Comments

  1. Rajat parhar

    Comorbidities prevalence and long term mortality will increase if we fall low in CRF categories . Exercise and second one could be the eating habits too , to be at top In CRF categories.

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